제약화장품학과

상세정보

- 송재경교수는 미국 Brown Univ. 생화학/대사공학/합성생물학 전공에서 이학박사를 취득하였다. 한국미생물생명공학회 분과회장, 한국방선균 연구회 회장, 한국당과학회 등을 역임했으며 선문대학교 건강보건대학 학장, 주산학 상생 제약산업 특화인력 양성산업단 단장, 선문대 생체분자재설계연구소 소장, 선문대학교 대학원 원장 등을 역임하며 활발한 연구활동을 해오셨다.
　

• 주요논문
  • Genome-enabled discovery of anthraquinone biosynthesis in Senna tora” Nat Commun.
  • Trilobatin ameliorates bone loss via suppression of osteoclast cell differentiation and bone resorptive function in vitro and in vivo” Life Sci.
  • Identification and enhancing production of a novel macrolide compound in engineered Streptomyces peucetius” RSC Advances
  • Genome mining Streptomyces sp. KCTC 0041BP as a producer of dihydrochalcomycin” Appl Microbiol Biotechnol.
  • Advances in biochemistry and the biotechnological production of taxifolin and its derivatives” Biotechnol Appl Biochem
  • Editorial: Recent Advances in Application of Synthetic Biology for Production of Bioactive Compounds” Front Bioeng Biotechnol.
  • Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways” Life Sci.
  • N-Glucosylation in Corynebacterium glutamicum with YdhE from Bacillus lichenformis” Molecules.
  • Functional Characterization of a Regiospecific Sugar- O-Methyltransferase from Nocardia” Appl Environ Microbiol.
  • Microbial Biosynthesis of Chrysazin Derivatives in Recombinant Escherichia coli and Their Biological Activities Molecules.
  • Increasing production of spinosad in Saccharopolyspora spinosa by metabolic engineering” Appl Environ Microbiol.
  • Biosynthetic pathway of peucemycin and identification of its derivative from Streptomyces peucetius” Appl Microbiol Biotechnol.

상세정보

- 이희찬 교수는 미국 Rice Univ.에서 생물공학/Biosafety 전공으로 공학박사를 취득했으며 롯데그룹중앙연구소 생물과학팀 연구원을 시작으로 한국화학공학회, 한국생물공학회 등 역임했다. 현재까지도 전략물자관리원 생물분야 심의위원, 질병관리본부 생물안전시설 분과위원, 통상산업부 생물무기금지협약 전문가, 한국바이오협회 특별회원 등으로 활동중이다.
　

• 주요논문
  • Enhanced proteomic analysis of Streptomyces peucetius Cytosolic protein using optimized protein solubilized protocol
  • Mediation of rubradirin resistance by ABC transporter (RubT1) from Streptomyces achromogenes var. rubradiris NRRL3061
  • An approach for cloning biosynthetic genes of 2-deoxystreptamine-containing aminocyclitol antibiotics: isolation of a biosynthetic gene cluster of tobramycin from Streptomyces tenebrarius
  • One-pot enzymatic production of dTDP-4-keto-6-deoxy-D-glucose from dTMP and glucose-1-phosphate
  • Identification of 2-Deoxy-scyllo-inosose synthase in aminoglycoside producer Streptomyces
  • Cystocin, a novel antibiotic, produced by Streptomyces sp. GCA0001
  • Mediation of Rubradirin Resistance by ABC transporters (RubT1) from Streptomyces achromogenes var. rubradiris NRRL3061
  • Identification of rub52 gene involed in the biosynthesis of rubradirin
  • One-pot enzymatic synthesis of UDP-D-glucose from UMP and glucose-1-phosphate using an ATP regeneration system
  • Molecular cloning and characterization of a 2-Deoxystreptamine biosynthetic gene cluster in gentamicin-producing Micromonospora echinospora ATCC15835
  • A gene cluster for the biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic cluster
  • Neocarzinostatin naphthoate synthase: an unique iterate type I PKS from neocarzinostaton producer Streptomyces carzinostaticus
  • Production of dTDP-4-keto-6-deoxy-D-glucose by immobilization of dTDP-D-glucose-4,6-dehydratase
  • Genome analyses of Streptomyces peucetius ATCC 27952 for the identification and comparison of cytochrome P450 complement with other Streptomyces
  • Cloning, expression and characterization of glucose-1- phosphate thymidylyltransferase (strmlA) from Thermus caldophilus
  • Optimization of the Expression of Streptomyces Venezuelae Cytochrome P450 Hydroxylase (PikC) in Escherichia coli
  • 미생물셀룰로오스로부터 탄소나노물질의 제조
  • 정제과정에 의한 탄화셀룰로오스 섬유구조의 증가
  • Novel method for detection of butanolides in Streptomyces coelicolor culture broth, using his-tagged receptor (ScbR) and Mass spectroscopy
  • Structural Diversification of Macrolactones by Substrate-Flexible Cytochrome P450 Monooxygenases
• 주요저서
  • 제약공학편찬위원회 “제약공학개론” 자유아카데미.

상세정보

- 오태진 교수는 선문대학교에서 생화학/대사공학 전공으로 이학박사를 취득했으며 유전체기반 바이오IT융합연구소 연구소장, BK21사업 교육연구단장, 바이오 빅데이터 기반 충남 스마트 클린 전문인력 양성사업단 등을 역임했다.
　

• 주요논문
  • Crystal structure and biochemical analysis of a cytochrome P450 steroid hydroxylase (BaCYP106A6) from Bacillus species. J. Microbiol. Biotechnol.
  • H2O2-driven hydroxylation of steroids catalyzed by cytochrome P450 CYP105D18: Exploration of the substrate access channel. Appl. Environ. Microbiol.
  • Complete genome sequence of the antibiotic-resistant Pseudomonas fluorescens strain Ant01, from rhizosphere of Antarctic moss. Microbiol. Resour. Announc.
  • Complete genome of Nakamurella sp. PAMC28650: Genomic insights into its environmental adaptation and biotechnological potential. Funct. Intergr. Genomics
  • Complete genome sequence and comparative genome analysis of Variovorax sp. strains PAMC28711, PAMC26660, and PAMC28562 and trehalose metabolic pathways in Antarctica isolates. Int. J. Microbiol.
  • Crystal structure and biochemical analysis of a cytochrome P450 CYP101D5 from Sphingomonas echinoides. Int. J. Mol. Sci. MDPI
  • Engineering of microbial substrate promiscuous CYP105A5 for improving the flavonoid hydroxylation. Catalysts MDPI
  • Structural basis for the substrate specificity of an S-formylglutathione hydrolase derived from Variovorax sp. PAMC 28711. Biochem. Biophys. Res. Comm.
  • n silico analysis and a comparative genomics approach to predict pathogenic trehalase genes in the complete genome of Antarctica Shigella sp. PAMC28760. Virulence
  • Complete genome sequencing of polar Arthrobacter sp. PAMC25284, copper tolerance potential unraveled with genomic analysis. Int. J. Microbiol.
  • Crystal structure of ChbG from Klebsiella pneumoniae reveals the molecular basis of diacetylchitobiose deacetylation. Commun. Biol.
  • Insight into glucocorticoids glucosylation by glucosyltransferase: A combined experimental and in-silico approach. Biophys. Chem.
  • AllEC: An Implementation of Application for EC Numbers Prediction based on AEC Algorithm. International Journal of Advanced Culture Technology
  • Comparative genome analysis among Variovorax species and genome guided aromatic compound degradation analysis emphasizing 4-hydroxybenzoate degradation in Variovorax
  • Comparative analysis of genome-based CAZyme cassette in Antarctic Microbacterium sp. PAMC28756 with 31 other Microbacterium species. Genes Genomics
  • GCRNN: graph convolutional recurrent neural networks for compound-protein interaction prediction. BMC Bioinformatics
• 주요저서
  • 제약공학편찬위원회 “제약공학개론” 자유아카데미.

상세정보

- 정혜진 교수는 세종대학교 의생명화학 전공에서 이학박사를 취득하였으며 연세대학교 생명공학과 선임연구원, 삼성서울병원 난치암연구사업단 선임연구원을 역임하였다.
　

• 주요논문
  • Cyclophilin A Inhibitors Suppress Proliferation and Induce Apoptosis of MKN45 Gastric Cancer Stem-like Cells by Regulating CypA/CD147-Mediated Signaling Pathway. Int J Mol Sci.
  • Novel terpestacin derivatives with l-amino acid residue as anticancer agents against U87MG-derived glioblastoma stem cells. Bioorg Chem.
  • Synergistic Anticancer Effect of a Combination of Berbamine and Arcyriaflavin A against Glioblastoma Stem-like Cells. Molecules.
  • Atorvastatin inhibits the proliferation of MKN45-derived gastric cancer stem cells in a mevalonate pathway-independent manner. Korean J Physiol Pharmacol.
  • Cyclophilin A/CD147 Interaction: A Promising Target for Anticancer Therapy. Int J Mol Sci.
  • Discovery of a New CaMKII-Targeted Synthetic Lethal Therapy against Glioblastoma Stem-like Cells. Cancers (Basel).
  • Anticancer Activity of Chloroform Fraction of Methanol Extract of Sparassis crispa in Human Cervical Cancer Stem Cells. Kor J Pharmacogn.
  • Anticancer activity of chloroform extract of Citrus unshiu Markovich peel against glioblastoma stem cells. Korean J Food Sci Technol.
  • The Natural Pigment Violacein Potentially Suppresses the Proliferation and Stemness of Hepatocellular Carcinoma Cells In Vitro. Int J Mol Sci.
  • Antiangiogenic and antitumor potential of berbamine, a natural CaMKIIγ inhibitor, against glioblastoma. Biochem Biophys Res Commun.
  • Ampelopsin Inhibits Cell Proliferation and Induces Apoptosis in HL60 and K562 Leukemia Cells by Downregulating AKT and NF-κB Signaling Pathways. Int J Mol Sci.
  • Identification of Cyclophilin A as a Potential Anticancer Target of Novel Nargenicin A1 Analog in AGS Gastric Cancer Cells. Int J Mol Sci.
  • Chloroform extract of Citrus unshiu Markovich peel induces apoptosis and inhibits stemness in HeLa human cervical cancer cells. Mol Med Rep.

상세정보

• 주요논문
  • Mechanical Characterization of P2 Bacteriophage by using a nanoindentation technique with atomic force microscopy
  • DNA 형태 적응을 거쳐 P2sir– 관련 도움파지 비효율성을 극복하는 박테리오파지 P4 sid+ 유도체 정성 연구
  • Construction and Characterization of the Bacteriophage P4 derivatives whose genome size suitable for packaging into a P2 sir3 –sized head
  • In Vitro Construction and Characterization of the Bacteriophage P4 Derivative, P4sid71 cos P2, Containing the Bacteriophage P2 cos Region
  • Isolation and Characterization of the smallest Bacteriophage P4 derivatives Packaged into P4-size Head in Bacteriophage P2-P4 System
  • Analysis of DNA Conformation in the Particles of Bacteriophage P4 Mutant, P4 ash8 sid71

• 주요저서
  • 기본 의약미생물학 및 실험
  • 생명과학 실험서
  • 미생물 유전학 실험

상세정보

- 최미영 교수는 Univ. of Chicago에서 분자세포생물학/미생물유전학 전공으로 이학박사를 취득했으며 University of Indiana에서 블루밍턴 방문학자, University of Pennsylvania에서 PostDoc. 등으로 활동했다.
　

• 주요논문
  • hnRNP E1 Interacts with hnRNP L
  • Identification of PABPN1 as an Interactive Protein of hnRNP L via Yeast Two-Hybrid Screening
  • Heterogeneous Nuclear Ribonucleoprotein D-like Protein JKTBP Interacts with Heterogeneous Nuclear Ribonucleoprotein K
  • Human Ribosomal Protein L18a Interacts with hnRNP E1

• 주요저서
  • 최미영, 핵심바이러스학 2021
  • 최미영 권혁빈, 분자생물학실험 2022
  • 최미영 장이섭, 피부과학의 이해 2023

상세정보

• 주요논문
  • 고추의 저온저항 관련 신호전달 기작의 연구
  • miRNA 관련 스트레스 내성 조절기작 연구
  • Genomics 및 epigenomics 시퀀싱 데이터 분석에 기반을 둔 벼의 drought stress 저항 관련 coding 및 noncoding 유전자의 특성 연구
  • Genomics 시퀀싱 데이터 분석에 기반을 둔 벼의 건조저항 및 질소대사관련 coding 및 noncoding 유전자의 특성 연구

• 주요저서
  • 일반생물학 실험서
  • 고교 생명과학 I&Ⅱ
  • 유전공학의 이해
  • 키포인트 생명과학
  • 분자생물학 실험서
  • 생명여행

상세정보

- 김승영 교수는 동경대학교에서 천연물화학 전공으로 농학박사를 받았다. 일본 동경대학교에서 농업응용생명공학연구과 연구교수, 스즈오카 대학교에서 식품응용생명과학과 조교수를 역임했으며 미국 University of Illinois at Urbana-Champaign에서는 박사 후 연구원을 하였다.
　

• 전문분야
  • 천연물을 이용한 생리활성물질 탐색, 효능 평가 및 기전 연구 (천연물화학)
  • 미생물의 생합성 메카니즘 규명 연구 (합성생물학, 미생물학, 생화학)
  • 새로운 biorenovation기법을 이용한 화장품 소재 탐색 및 효능평가 (화장품화학)
  • 미생물을 이용한 산업화 균주 개발 (대사공학, 효소공학)
  • 마이크로니들 연구 개발 및 약물전달 시스템 소재 개발

• 주요논문
  • Dimethyl Itaconate Reduces α-MSH-Induced Pigmentation via Modulation of AKT and p38 MAPK Signaling Pathways in B16F10 Mouse Melanoma Cells. Molecule
  • Anti-inflammatory effect of Althaea rosea L. Callus extract by applying biorenovation. Journal of Applied Biological Chemistry
  • Anti-inflammatory effect of naringenin-7-O-phosphate in LPS-induced RAW 264.7 cells, J. Appl. Biol. Chem.
  • Effects of Luteolin-7-O-glucoside on Melanin Synthesis. J. Appl. Biol. Chem.2022
  • Anti-inflammatory effect of soil blue-green algae Nostoc commune isolated from Daejeon National Cemetery. JABC
  • Anti-inflammatory Activities of 7,8-Dihydroxy-4-methylcoumarin Acetylation Products via the NF-κB and MAPK Pathways in LPS-stimulated RAW 264.7 Cells. Natural Product Communications,
  • Synthesis and Melanogenesis Effect of 7,8-Dimethoxy-4-Methylcoumarin via MAPK Signaling-Mediated Microphthalmia-Associated Transcription Factor Upregulation. Natural Product Communications
  • Anti-Inflammatory Effect of Crypsinus hastatus Biorenovation Extract. JABC ournal
  • Anti-inflammatory activity of 6-O-phospho-7-hydroxycoumarin in LPS-induced RAW 264.7 cells. JABC ournal
  • Prunetin 4′-O-Phosphate, a Novel Compound, in RAW 264.7 Macrophages Exerts Anti-Inflammatory Activity via Suppression of MAP Kinases and the NFκB Pathway. Molecules
  • Luteolin-3′-O-Phosphate Inhibits Lipopolysaccharide-Induced Inflammatory Responses by Regulating NF-κBMAPK Cascade Signaling in RAW 264.7 Cells. Molecules
  • Anti-inflammatory effect of Distylium racemosum leaf biorenovate extract in LPS-stimulated RAW 264.7 macrophages cells. JABC ournal
  • Biorenovation-Assisted Modifiction of Ligustrum japonicum Extract forSkin-Whitening Effect. KSBB Journal
  • Anti-inflammatory Activity of Beta vulgaris Extract Using Biorenovation in LPS-stimulated RAW 264.7 Cells. KSBB Journal
  • The Effects of Gleditsia japonica Extract Following Biorenovation on Melanogenesis-related genes in B16F10 Melanoma Cells. KSBB Journal
  • Melanogenesis Inhibitory Effects of Phryma leptostachya Callus using Biorenovation in B16F10 Melanoma Cells. KSBB Journal